WORLD / Health
New breath test detects lung cancer
(Agencies)
Updated: 2007-07-14 05:12
Testing exhaled breath with a small sensor array can detect lung cancer
with moderate accuracy, researchers report.
The testing device, which contains 36 spots impregnated with chemically
sensitive compounds, works by detecting patterns of volatile organic
compounds in exhaled breath. These spots change colors when exposed to
particular chemicals.
The goal of the study reported in the medical journal Thorax was to
determine if various color patterns could be identified that accurately
detect lung cancer.
The study included 49 patients with non-small-cell lung cancer, 73 with
various other, non-malignant lung diseases, and 21 healthy "controls."
Data from 70 percent of the subjects were used to identify a pattern that
indicated the presence of lung cancer, which was then tested in the
remaining 30 percent.
The predictive pattern identified by the researchers was able to spot 73
percent of cancers, while it incorrectly identified 28 percent of
nonmalignant conditions as cancerous.
"Further work may clarify the nature of the distinct breath
constituents," conclude Dr. Peter J. Mazzone, from The Cleveland Clinic,
Ohio, and colleagues. "This would help to guide refinement of the sensor
array and breath collection system to maximize the diagnostic accuracy of
the test."
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